井淼

生物体通过多系统之间的协同作用维持其正常的生理功能。在其中，神经递质、激素等化学小分子在细胞间信息沟通和交流中起到不可或缺的作用。我们课题组试图通过开发新的技术手段，为寻找新的信息传递分子、实时观测小分子动态变化以及最终解析其在特定生理调控，尤其是神经-免疫相互作用中的功能提供新的途径。

1、Luan P, Jia J, Chen Y, Xi F, Schwarcz AD, Jiang X, Környei Z, Kalmár B, Wang Y, Dénes Á, Jing M. A reciprocal glial circuit calibrates injury information and governs the tissue response balance. Neuron. 2026 Apr 15:S0896-6273(26)00222-9. doi: 10.1016/j.neuron.2026.03.031. PMID: 41990745  

2、Zhao J, Zhou L, Wang C, Rao Z, Yuan X, Cui J, Zhao D, Sun Y, Chen Y, Li R, Jing M. Epidermal PAR2-TRPV3-IL-33 Signaling Promotes Mast Cell Recruitment and Sensory Nerve-Mast Cell Interactions in Atopic Dermatitis. Allergy. 2026 May;81(5):1898-1901. doi: 10.1111/all.70284. Epub 2026 Mar 8. PMID: 41795617; PMCID: PMC13139801.

3、Wu R, Li N, Wen Z, Wang Y, Li S, Zhou H, Huang Y, Xie X, Zhao X, Wang X, Tao S, Chai G, Wang TA, Li Z, Chen PR, Jing M. Photo-cross-linking-assisted deorphanization deciphers GPR50-L-LEN pairing in metabolism. Nat Chem Biol. 2026 Jan 6. doi: 10.1038/s41589-025-02098-6. Epub ahead of print. PMID: 41495223.

4、Xi F, Wang C, Wang Y, Luan P, Chen Y, Tan L, Shang N, Gao X, Chen D, Guo Q, Chen T, Jing M. Spatiotemporal dynamics of CXCL10 encode contextual immune information revealed by the genetically encoded fluorescent sensor. Immunity. 2025 Sep 9;58(9):2320-2335.e9. doi: 10.1016/j.immuni.2025.07.005. Epub 2025 Aug 15. Erratum in: Immunity. 2026 Mar 6:S1074-7613(26)00090-7. doi: 10.1016/j.immuni.2026.02.020. PMID: 40818452.

5、Chen Y, Luan P, Liu J, Wei Y, Wang C, Wu R, Wu Z, Jing M. Spatiotemporally selective astrocytic ATP dynamics encode injury information sensed by microglia following brain injury in mice. Nat Neurosci. 2024 Aug;27(8):1522-1533. doi: 10.1038/s41593-024-01680-w. Epub 2024 Jun 11. PMID: 38862791.

6、Wu Z, He K, Chen Y, Li H, Pan S, Li B, Liu T, Xi F, Deng F, Wang H, Du J, Jing M, Li Y. A sensitive GRAB sensor for detecting extracellular ATP in vitro and in vivo. Neuron. 2022 Mar 2;110(5):770-782.e5. doi: 10.1016/j.neuron.2021.11.027. Epub 2021 Dec 22. PMID: 34942116.

7、Wan J, Peng W, Li X, Qian T, Song K, Zeng J, Deng F, Hao S, Feng J, Zhang P, Zhang Y, Zou J, Pan S, Shin M, Venton BJ, Zhu JJ, Jing M, Xu M, Li Y. A genetically encoded sensor for measuring serotonin dynamics. Nat Neurosci. 2021 May;24(5):746-752. doi: 10.1038/s41593-021-00823-7. Epub 2021 Apr 5. PMID: 33821000; PMCID: PMC8544647.

8、Jing M, Li Y, Zeng J, Huang P, Skirzewski M, Kljakic O, Peng W, Qian T, Tan K, Zou J, Trinh S, Wu R, Zhang S, Pan S, Hires SA, Xu M, Li H, Saksida LM, Prado VF, Bussey TJ, Prado MAM, Chen L, Cheng H, Li Y. An optimized acetylcholine sensor for monitoring in vivo cholinergic activity. Nat Methods. 2020 Nov;17(11):1139-1146. doi: 10.1038/s41592-020-0953-2. Epub 2020 Sep 28. PMID: 32989318; PMCID: PMC7606762.

9、Jing M, Zhang Y, Wang H, Li Y. G-protein-coupled receptor-based sensors for imaging neurochemicals with high sensitivity and specificity. J Neurochem. 2019 Nov;151(3):279-288. doi: 10.1111/jnc.14855. Epub 2019 Oct 13. PMID: 31419844; PMCID: PMC6819231.

10、Feng J, Zhang C, Lischinsky JE, Jing M, Zhou J, Wang H, Zhang Y, Dong A, Wu Z, Wu H, Chen W, Zhang P, Zou J, Hires SA, Zhu JJ, Cui G, Lin D, Du J, Li Y. A Genetically Encoded Fluorescent Sensor for Rapid and Specific In Vivo Detection of Norepinephrine. Neuron. 2019 May 22;102(4):745-761.e8. doi: 10.1016/j.neuron.2019.02.037. Epub 2019 Mar 25. PMID: 30922875; PMCID: PMC6533151.

11、Wu Z, Feng J, Jing M, Li Y. G protein-assisted optimization of GPCR-activation based (GRAB) sensors. Neural Imaging and Sensing 2019. Vol. 10865. SPIE, 2019.

12、Jing M, Zhang P, Wang G, Feng J, Mesik L, Zeng J, Jiang H, Wang S, Looby JC, Guagliardo NA, Langma LW, Lu J, Zuo Y, Talmage DA, Role LW, Barrett PQ, Zhang LI, Luo M, Song Y, Zhu JJ, Li Y. A genetically encoded fluorescent acetylcholine indicator for in vitro and in vivo studies. Nat Biotechnol. 2018 Sep;36(8):726-737. doi: 10.1038/nbt.4184. Epub 2018 Jul 9. PMID: 29985477; PMCID: PMC6093211.

13、Sun F, Zeng J, Jing M, Zhou J, Feng J, Owen SF, Luo Y, Li F, Wang H, Yamaguchi T, Yong Z, Gao Y, Peng W, Wang L, Zhang S, Du J, Lin D, Xu M, Kreitzer AC, Cui G, Li Y. A Genetically Encoded Fluorescent Sensor Enables Rapid and Specific Detection of Dopamine in Flies, Fish, and Mice. Cell. 2018 Jul 12;174(2):481-496.e19. doi: 10.1016/j.cell.2018.06.042. PMID: 30007419; PMCID: PMC6092020.

14、Wang H, Jing M, Li Y. Lighting up the brain: genetically encoded fluorescent sensors for imaging neurotransmitters and neuromodulators. Curr Opin Neurobiol. 2018 Jun;50:171-178. doi: 10.1016/j.conb.2018.03.010. Epub 2018 Apr 5. PMID: 29627516; PMCID: PMC5984720.